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CHOP monoclonal antibody (9C8)

ALX-804-551

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CHOP is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP α and β. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP-CHOP dimer gains binding activity to other non-classical C/EBP stress related targets.
Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of CHOP inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane.

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This antibody is covered by our Worry-Free Guarantee.

Presenilin 1 monoclonal antibody (APS 11) Immunocytochemistry

Product Details

Alternative Name	C/EBP homology protein, Growth arrest and DNA damage inducible protein 153, GADD153
Application	ICC, IP, WB
Application Notes	Detects a band of ~31kDa by Western blot.
Clone	9C8
Formulation	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
Host	Mouse
Immunogen	Recombinant mouse CHOP (C/EBP homology protein).
Isotype	IgG2b
Recommendation Dilutions/Conditions	Western Blot (1µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human, Mouse
Specificity	Recognizes an N-terminal epitope.
UniProt ID	P35639
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Heat Shock Protein 47 Maintains Cancer Cell Growth by Inhibiting the Unfolded Protein Response Transducer IRE1α.: Yoneda, A., Tamura, Y., et al.; Mol. Cancer Res. 18, 847 (2020), Application(s): WB, Abstract
Endoplasmic reticulum stress in the dorsal root ganglia regulates large-conductance potassium channels and contributes to pain in a model of multiple sclerosis: Yousuf, M. S., Samtleben, S., et al.; FASEB J. 34, 12577 (2020), Abstract
ER stress-mediated BK dysfunction in the DRG underlies pain in a model of multiple sclerosis: Yousuf, M. S., Samtleben, S., et al.; bioRxiv , (2020)
NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization.: Nukina, N., Koike, M., et al.; Nat. Commun. 5, 3354 (2014), Application(s): WB / Reactant(s): Mouse, Abstract
Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim: L. Happo, et al.; Blood 116, 5256 (2010), Abstract
Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells: P.K. Chakraborty, et al.; Mol Cancer 9, 102 (2010), Abstract
Regulated increase in folding capacity prevents unfolded protein stress in the ER: C. Christis, et al.; J. Cell. Sci. 123, 787 (2010), Abstract
Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses: A.O. Gramolini, et al.; Mol. Cell Proteomics 7, 519 (2008), Abstract
Induction of a secreted protein by the myxoid liposarcoma oncogene: M. Kuroda, et al.; PNAS 96, 5025 (1999), Abstract — Full Text
CHOP-Dependent stress-inducible expression of a novel form of carbonic anhydrase VI: J. Sok, et al.; Mol. Cell. Biol. 19, 495 (1999), Abstract — Full Text

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CHOP monoclonal antibody (9C8)

ALX-804-551

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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