Home Shop Cholera toxin (Vibrio cholerae), (azide free)

Cholera toxin (Vibrio cholerae), (azide free)

BML-G117

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G protein activator

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Cholera toxin consists of a single A subunit surrounded by five B subunits. The B subunits are responsible for the attachment of the native toxin to ganglioside GM1 on mammalian cell surfaces, and facilitate translocation of the A subunit. The A subunit catalyzes the ADP-ribosylation of an arginine residue on the a subunit of G proteins, reducing intrinsic GTPase activity and activating the a subunit. ADP-ribosylation of other proteins such as human red cell Ca-ATPase has also been reported. Cholera toxin must interact with ADP-ribosylation factor (ARF) for maximal activity.

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Product Details

CAS	9012-63-9
Formulation	Lyophilized from 0.05M Tris, pH 7.5, containing 200 mM NaCl, and 1 mM Na₂ EDTA.
Reconstitution	Reconstitute with 0.5ml sterile water to a 2mg/mL solution.
Source	From Vibrio cholerae.
UniProt ID	P01555 (A subunit), P01556 (B subunit)

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Handle gently and do not vortex. Store at +4°C prior to and following reconstitution. Do not freeze.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A survey of CIN measures across mechanistic models: Lynch, A. R., Bradford, S., et al.; bioRxiv , (2023)
HER2 Cellular Localization, Cell-Cell Contacts, and Cell Density Regulate Cancer Cell Plasticity in HER2+ Breast Cancer: Sameri, S., Das, D., et al.; bioRxiv , (2023)
A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells: A.M. Porman, et al.; PLoS Biol. 20, e3001885 (2022), Abstract
Diallyl Sulfide Attenuation of Carcinogenesis in Mammary Epithelial Cells through the Inhibition of ROS Formation, and DNA Strand Breaks: S.F. Darling-Reed, et al.; Biomolecules 11, 1313 (2021), Abstract
Caco-2/HT29-MTX co-cultured cells as a model for studying physiological properties and toxin-induced effects on intestinal cells: P. Hoffmann, et al.; PLoS One 16, e0257824 (2021), Abstract