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CHD3 is a subunit of the histone deacetylase NuRD complex involved in nucleosme remodeling, core histone post-translational modifications and transcriptional regulation. It belongs to a family of SNF2-related nucleosome remodeling enzymes (DNA-dependent ATPases). These ATP-dependent motor proteins are major factors of chromatin structure and transcriptional control in vivo. SNF2-related factors have been implicated in a variety of cancers in humans.
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