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Cell permeable, potent and selective inhibitor of CDK1/cyclin B (IC50=25nM). Reported to affect the activities of other kinases only at much higher concentrations: PKCα (IC50=6.1µM), PKA (IC50=125µM) and EGFR (IC50>10µM). Induces mitochondrial damage and apoptosis in several human leukemia cell lines (>3µM).
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| Regulatory Status |
RUO – Research Use Only |
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