CGP-37157

BML-CM119

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MPTP inhibitor

Potent, selective inhibitor of mitochondrial Na⁺Ca²⁺ exchange. IC₅₀=0.4µM. Blocks mitochondrial permeability transition.

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Product Details

Appearance	White solid.
CAS	75450-34-9
Couple Target	MPTP
Couple Type	Inhibitor
Formula	C₁₅H₁₁Cl₂NOS
MW	324.2
Purity	≥98% (TLC)
Solubility	Soluble in DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Dependence of mitochondrial calcium signalling and dynamics on the disaggregase, CLPB: D’Angelo, D., Sánchez-Vázquez, V. H., et al.; Nat. Commun. 16, 2810 (2025), Abstract
TMEM65 regulates and is required for NCLX-dependent mitochondrial calcium efflux: Garbincius, J. F., Salik, O., et al.; Nat. Metab. 7, 714 (2025), Abstract
MCU gain-and loss-of-function models define the duality of mitochondrial calcium uptake in heart failure: Garbincius, J. F., Luongo, T. S., et al.; bioRxiv , (2023)
MICU1 controls the sensitivity of the mitochondrial Ca2+ uniporter to activators and inhibitors: Rodriguez-Prados, M., Huang, K. T., et al.; Cell Chem. Biol. 30, 606 (2023), Abstract
TMEM65 regulates NCLX-dependent mitochondrial calcium efflux: Garbincius, J. F., Salik, O., et al.; bioRxiv , (2023)
Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart: S. De La Fuente, et al.; Cell Rep. 24, 3099 (2018), Abstract
MICU1 Confers Protection from MCU-Dependent Manganese Toxicity: J. Wettmarchausen, et al.; Cell Rep. 25, 1425 (2018), Abstract
MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360: Paillard, M., Csordás, G., et al.; Mol. Cell 72, 778 (2018), Abstract
Mitochondria fine-tune the slow Ca2+ transients induced by electrical stimulation of skeletal myotubes: V. Eisner, et al.; Cell Calcium 48, 358 (2010), Abstract
Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157: D. A. Cox, et al.; J. Cardiovasc. Pharmacol. 21, 595 (1993), Abstract

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CGP-37157

BML-CM119

Product Details

Handling & Storage

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