Cerulenin

BML-G237

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Fatty acid synthase inhibitor

Antibiotic. Fatty acid synthase (FAS) inhibitor reported to bind in equimolar ratio to β-keto-acyl-ACP synthase (KAS; IC₅₀=1.5µM), thus inhibiting protein acylation at concentrations of 45-134 µM. Produces metabolic effects similar to the effects of leptin, but through mechanisms that are independent of, or down-stream from, both leptin and melanocortin receptors. Apoptosis inducer. Inhibitor of bacterial fatty acid synthesis (inhibits FabH, FabB and FabF condensation enzymes).

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Product Details

Alternative Name	2,3-Epoxy-4-oxo-7,10-dodecadienamide
Appearance	White to off-white solid.
CAS	17397-89-6
Couple Target	Fatty acid synthase
Couple Type	Inhibitor
Formula	C₁₂H₁₇NO₃
MI	14: 2004
MW	223.3
Purity	≥98% (TLC)
RTECS	JR1670000
Solubility	Soluble in DCM (5mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Coordinated Regulation of Membrane Homeostasis and Drug Accumulation by Novel Kinase STK-17 in Response to Antifungal Azole Treatment: C. Hu, et al.; Microbial Spectr. 10, e0012722 (2022), Abstract
The Multiple DSF-family QS Signals are Synthesized from Carbohydrate and Branched-chain Amino Acids via the FAS Elongation Cycle: L. Zhou, et al.; Sci. Rep. 5, 13294 (2015), Application(s): Cell culture, Abstract
Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells: T.S. Ho, et al.; Biomed. Pharmacother. 61, 578 (2007), Abstract
Expression and functional characterization of a giant Type I fatty acid synthase (CpFAS1) gene from Cryptosporidium parvum: G. Zhu, et al.; Mol. Biochem. Parasitol. 134, 127 (2004), Abstract
Identification and molecular characterization of the beta-ketoacyl-[acyl carrier protein] synthase component of the Arabidopsis mitochondrial fatty acid synthase: R. Yasuno, et al.; J. Biol. Chem. 279, 8242 (2004), Abstract
Key role of mitochondria in cerulenin-mediated apoptosis: S.J. Heiligtag, et al.; Cell Death Differ. 9, 1017 (2002), Abstract
Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting: H. Makimura, et al.; Diabetes 50, 733 (2001), Abstract — Full Text
Cerulenin-resistant mutants of Saccharomyces cerevisiae with an altered fatty acid synthase gene: J. Inokashi, et al.; Mol. Gen. Genet. 244, 90 (1994), Abstract
Effect of cerulenin on the synthesis of very-long-chain fatty acids in microsomes from leek seedlings: F. Schneider, et al.; Biochim. Biophys. Acta 1152, 243 (1993), Abstract
Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins: S.A. Metz, et al.; Biochem. J. 295, 31 (1993), Abstract

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Cerulenin

BML-G237

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