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CENP-A monoclonal antibody (3-19)

ADI-KAM-CC006

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Centromere protein A (CENP-A), a 17-19 kDa centromere-specific histone variant, is 62% identical to the carboxy-terminal domain of histone H3. In the presence of DNA, CENP-A forms an octameric complex with histones H4, H2A, and H2B. CENP-A defines active centromere regions by forming centromere-specific nucleosomes on which kinetochores are assembled. CENP-A resides specifically in the inner plate of the kinetochore, and is essential for kinetochore targeting of CENP-C and other kinetochore components. CENP-A is required for nucleosomal packaging of centromeric DNA at interphase.

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CENP-A monoclonal antibody (3-19) Immunohistochemistry — Immunohistochemical detection of CENP-A on paraffin embedded section of a squamous epithelium of human tonsil.

CENP-A monoclonal antibody (3-19) Western blot — Western blot analysis of Jurkat (1), Raji (2), PC12 (3), Rat-1 (4), WR19L (5), C2C12 (6), and NIH3T3 (7) cell lysates probed with CENP-A mAb (3-19).

CENP-A monoclonal antibody (3-19) Immunocytochemistry — Immunocytochemical detection of CENP-A on acetone fixed HEp-II with CENP-A mAb (3-19).

Product Details

Alternative Name	Centromere protein A
Application	ICC, IHC, WB
Application Notes	Detects bands of ~18kDa by Western blot.
Clone	3-19
Formulation	Liquid. In PBS, pH 7.2, containing 50% glycerol.
Host	Mouse
Immunogen	Synthetic peptide corresponding to a portion of human CENP-A .
Isotype	IgG1
Purity Detail	Protein A affinity purified.
Recommendation Dilutions/Conditions	Immunocytochemistry (10µg/ml)Immunohistochemistry (5µg/ml)Western Blot (1µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human
UniProt ID	P49450
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

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Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Centromeric transposable elements and epigenetic status drive karyotypic variation in the eastern hoolock gibbon: Hartley, G. A., Okhovat, M., et al.; Cell Genom. 5, 100808 (2025), Abstract
Heterochromatin boundaries maintain centromere position, size and number: Carty, B. L., Dubocanin, D., et al.; bioRxiv , (2025)
Conservation of dichromatin organization along regional centromeres: Dubocanin, D., Hartley, G. A., et al.; Cell Genom. 5, 100819 (2025), Abstract
Epigenetically dynamic human centromeres are maintained within a stable DNA methylation signature: Mahlke, M. A., Lumerman, L., et al.; bioRxiv , (2025)
DNAJC9 prevents CENP-A mislocalization and chromosomal instability by maintaining the fidelity of histone supply chains.: Balachandra, V., Shrestha, R. L., et al.; EMBO J. 43, 2166 (2024), Application(s): WB, Abstract
Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin: Sacristan, C., Samejima, K., et al.; Cell 187, 3006 (2024), Abstract
The variation and evolution of complete human centromeres: Logsdon, G. A., Rozanski, A. N., et al.; Nature 629, 136 (2024), Abstract
Centromeric transposable elements and epigenetic status drive karyotypic variation in the eastern hoolock gibbon: Hartley, G. A., Okhovat, M., et al.; bioRxiv , (2024)
β-TrCP-Mediated Proteolysis of Mis18β Prevents Mislocalization of CENP-A and Chromosomal Instability.: Sethi, S. C., Shrestha, R. L., et al.; Mol. Cell. Biol. 44, 429 (2024), Reactant(s): Human, Abstract
The bromodomain inhibitor JQ1 is a molecular glue targeting centromeres: Corless, S., Pratap-Singh, N., et al.; bioRxiv , (2023)

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CENP-A monoclonal antibody (3-19)

ADI-KAM-CC006

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Handling & Storage

Datasheet, Manuals, SDS & CofA

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