Celastrol

ALX-350-332

Datasheet
Manual
SDS
CofA

Already have an account?

Anti-inflammatory and immunosuppressive

Cell permeable triterpenoid; anti-inflammatory and immunosuppressive compound. Antioxidant. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC₅₀=40nM for IL-1β and IL-1α, 80nM for IL-6, 110nM for prostaglandin E₂ and 210nM for IL-8 and TNF-α). Suppresses nitric oxide (NO) production (IC₅₀=230nM) and LPS-induced NF-κB activation (IC₅₀=270nM). Inhibits chymotrypsin-like activity of 20S proteasome (IC₅₀=2.5µM). Inhibits lipid peroxidation induced by ADP and Fe²⁺ in rat liver mitochondria (IC₅₀=7µM). Induces expression of a wider set of heat shock proteins. Inhibits topoisomerase II.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	Tripterine, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid
Appearance	Red cubic crystals.
CAS	34157-83-0
Couple Target	Proteasome, Topoisomerase
Couple Type	Inhibitor
Formula	C₂₉H₃₈O₄
MI	14: 10370
MW	450.6
Purity	≥98% (HPLC)
Solubility	Soluble in 100% ethanol, DMSO or dimethyl formamide; insoluble in water.
Source	Isolated from the root of Tripterygium sp.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The cryoprotective effects of celastrol nanoemulsion on post-thawed attributes and fertilizing ability of cryopreserved buffalo semen: Khalil, W. A., Elkhamy, S. A., et al.; Vet. Res. Commun. 49, 214 (2025), Abstract
Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase Iiα: I.N. Cvijetić, et al.; Pharmaceuticals 16, 341 (2023), Abstract
Cannabis sativa Extract Induces Apoptosis in Human Pancreatic 3D Cancer Models: Importance of Major Antioxidant Molecules Present Therein: F. Emhemmed, et al.; Molecules 27, 1214 (2022), Abstract
Cytotoxic and Pro-Apoptotic Effects of Leaves Extract of Antiaris africana Engler (Moraceae): Thiam, K., Zhao, M., et al.; Molecules 27, (2022), Abstract
Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex: Ding, S., Mooney, N., et al.; PLoS Pathog. 12, e1005929 (2016), Abstract
Phenotype-specific apoptosis induced by three new triterpenoid saponins from Albizia glaberrima (Schumach. & Thonn.) Benth: O.P. Noté, et al.; Fitoterapia 109, 80 (2015), Application(s): Used as a positive control, Abstract
Induction of heat shock proteins in differentiated human and rodent neurons by celastrol: A.M. Chow & I.R. Brown; Cell Stress Chaperones 12, 237 (2007), Abstract
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation: G. Sethi, et al.; Blood 109, 2727 (2007), Abstract
Tripterine inhibits the expression of adhesion molecules in activated endothelial cells: D. H. Zhang, et al.; J. Leukoc. Biol. 80, 309 (2006), Abstract — Full Text
Celastrol, a triterpene extracted from the Chinese Thunder of God Vine,” is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice”””: H. Yang, et al.; Cancer Res. 66, 4758 (2006), Abstract — Full Text

Related Products

Pristimerin

ALX-350-411

Antitumor agent

17 citations

Alternative Name	Celastrol methyl ester
CAS	1258-84-0
Couple Type	Inhibitor
Purity	≥97% (HPLC)

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

Celastrol

ALX-350-332

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project