Home Shop CEACAM6 (human) monoclonal antibody (9A6)

CEACAM6 (human) monoclonal antibody (9A6)

ALX-805-083

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The normal cross-reacting antigen (NCA) or CEACAM6 belongs to the carcinoembryonic antigen (CEA) gene family. CEACAM6 is a GPI-anchored membrane protein with a single N domain, which shows structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like domains.

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This antibody is covered by our Worry-Free Guarantee.

Product Details

Alternative Name	CD66c, NCA
Application	ELISA, Flow Cytometry, IHC (FS), WB
Clone	9A6
Crossreactivity	Does not cross-react with human CEACAM1, 3, 4, 5, 7 or 8.
Formulation	Liquid. In PBS, pH 7.2. Contains no preservatives.
Host	Mouse
Immunogen	Tumor cell lines expressing human CEACAM6.
Isotype	IgG1
Purity Detail	Protein G-affinity purified.
Quality Control	Routinely tested by flow cytometry on BOSC cells transiently transfected with a NCA expression vector.
Species Reactivity	Human
UniProt ID	P40199
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens: T. Schmitter, et al.; J. Exp. Med. 199, 35 (2004), Abstract — Full Text
Carcinoembryonic antigen: W. Zimmermann; Wiley Encyclopedia of Molecular Medicine , 459 (2002), (Book chapter)
Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes: B.B. Singer, et al.; J. Immunol. 168, 5139 (2002), Abstract — Full Text
Nuclear factor-kappa B directs carcinoembryonic antigen-related cellular adhesion molecule 1 receptor expression in Neisseria gonorrhoeae-infected epithelial cells: P. Muenzner, et al.; J. Biol. Chem. 277, 7438 (2002), Abstract — Full Text
Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site: S.M. Watt, et al.; Blood 98, 1469 (2001), Abstract — Full Text
Pathogenic Neisseria trigger expression of their carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1; previously CD66a) receptor on primary endothelial cells by activating the immediate early response transcription factor, nuclear facto: P. Muenzner, et al.; J. Biol. Chem. 276, 24331 (2001), Abstract — Full Text
Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas: S. Scholzel, et al.; Am. J. Pathol. 156, 595 (2000), Abstract — Full Text
Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells: P. Muenzner, et al.; Infect. Immun. 68, 3601 (2000), Abstract — Full Text
CEA-related proteins on human urothelial cell lines of different transformation grades: A. Krop-Watorek, et al.; Cancer Lett. 139, 15 (1999), Abstract
Opa binding to cellular CD66 receptors mediates the transcellular traversal of Neisseria gonorrhoeae across polarized T84 epithelial cell monolayers: J. Wang, et al.; Mol. Microbiol. 30, 657 (1998), Abstract — Full Text

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CEACAM6 (human) monoclonal antibody (9A6)

ALX-805-083

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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