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CDK1/2 Inhibitor III

ALX-270-442

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Cell permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC₅₀=20nM, 35nM and 92nM in HCT-116, HeLa, and A375 cells). Acts as a highly potent, ATP-competitive inhibitor of CDK1/cyclin B and CDK2/cyclin A (IC₅₀=600pM and 500pM) with selectivity over VEGF-R2 and GSK-3β (IC₅₀=32nM and 140nM).

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Product Details

Alternative Name	5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
Appearance	White to off-white solid.
CAS	443798-55-8
Couple Target	CDK, GSK, VEGFR
Couple Type	Inhibitor
Formula	C₁₅H₁₃F₂N₇O₂S₂
Identity	Identity determined by NMR.
MW	425.4
Purity	≥95% (HPLC)
Solubility	Soluble in DMSO (10mg/ml), tetrahydrofuran or acetone.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 6 months when stored at -20°C.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Cyclin-Dependent Kinase 1 Inhibition Potentiates the Proliferation of Tonsil-Derived Mesenchymal Stem Cells by Delaying Cellular Senescence: D.H. Choi, et al.; Stem Cells Int. 2022, 4302992 (2022), Abstract
Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation: Yatskevich, S., Kroonen, J. S., et al.; Cell Rep. 34, 108929 (2021), Abstract
Molecular mechanism of APC/C activation by mitotic phosphorylation: Zhang, S., Chang, L., et al.; Nature 533, 260 (2016), Abstract
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities: R. Lin, et al.; J. Med. Chem. 48, 4208 (2005), Abstract

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CDK1/2 Inhibitor III

ALX-270-442

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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