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CDC25 protein tyrosine phosphatases activate cyclin dependent kinases by dephosphorylating them, promoting cell division. All three of the genes encoding the CDC25 phosphatases are considered potential oncogenes and the enzymes are drug discovery targets. CDC25C activates CDC2/cyclin B which controls entry into mitosis. CDC25C, itself, is regulated by phosphorylation and binding to 14-3-3 proteins.
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