CDC25B (human), (recombinant)

CDC25 protein tyrosine phosphatases activate cyclin dependent kinases by dephosphorylating them, promoting cell division. All three of the genes encoding the CDC25 phosphatases are considered potential oncogenes and the enzymes are drug discovery targets. In mammalian cells, the CDC25B isoform activates cyclin A- and cyclin B1-containing complexes and is necessary for entry into mitosis. CDC25B -/- female mice are sterile because their oocytes are in permanent meiotic arrest resulting from the inability to activate CDK11. CDC25B shuttles between the nucleus and the cytoplasm. The protein is in the nucleus during M and G1 and moves to the cytoplasm during S and G22.