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Lipoxygenase inhibitor

Selective 12-lipoxygenase inhibitor. IC₅₀=0.063 µM, 3.33 µM and 1.89 µM for 12-, 15- and 5-LO respectively in isolated enzyme preparations.

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CAS	132465-11-3
Couple Target	Lipoxygenase
Couple Type	Inhibitor
MW	321.3
Purity	≥98%
Solubility	Soluble in ethanol (5mg/ml) or DMSO (5mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 1 year. Store under nitrogen after opening. Product is subject to oxidation. Make solutions fresh daily.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis: J. Chan, et al.; FASEB J. 32, 3816 (2018), Application(s): Inhibition of 12(S)-HETE biosynthesis in mice, Abstract
Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2): Ashley, J. W., Hancock, W. D., et al.; J. Biol. Chem. 291, 23268 (2016), Abstract
Mechanisms underlying increased reactivity of pulmonary arteries contralateral to a localized high-flow anastomosis: S. Pfister, et al.; J. Thorac. Cardiovasc. Surg. 141, 425 (2011), Abstract — Full Text

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