CD57 monoclonal antibody (NK-1)

Anti-CD57 marks a subset of lymphocytes known as natural killer (NK) cells. Follicular center cell lymphomas often contain many NK cells within the neoplastic follicles. Anti-CD57 also stains neuroendocrine cells and their derived tumors, including carcinoid tumor and medulloblastoma. Anti-CD57 can also be useful in separating type B3 thymoma from thymic carcinoma when combined with a panel that includes antibodies against GLUT1, CD5 and CEA.

CD57, also known as HNK-1 (human natural killer-1), is a cell surface marker associated with specific immune cell populations. It plays a crucial role in immune response modulation, neurobiology, and various pathological conditions. CD57 is a glycoprotein expressed on the surface of certain immune cells, including natural killer (NK) cells, T cells, and subsets of B cells. In the immune system, CD57 serves as a marker for identifying specific subsets of lymphocytes. Elevated CD57 expression on NK cells, for example, is linked to enhanced cytotoxicity and a more robust immune response against infected or aberrant cells. Additionally, CD57 can be used to distinguish memory T cell subsets, providing insights into the immune system’s adaptive memory.