Home Shop CD51 (human) monoclonal antibody (L230)

CD51 (human) monoclonal antibody (L230)

ALX-803-304

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CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3 is also highly expressed in osteoclasts being important for bone resorption.

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This antibody is covered by our Worry-Free Guarantee.

Product Details

Alternative Name	αV integrin, Vitronectin receptor α subunit
Application	ELISA, Flow Cytometry, FUNC, IF, IHC, IP
Application Notes	Functional Application: αV integrin blocking
Clone	L230
Crossreactivity	Does not cross-react with other species.
Formulation	Liquid. In PBS containing 0.05% sodium azide.
Host	Mouse
Immunogen	Human endothelial cells.
Isotype	IgG1
Purity Detail	Protein A-affinity purified.
Species Reactivity	Human
Specificity	Recognizes heterodimers αVβ3, αVβ1, αVβ5 and αVβ6.
UniProt ID	P06756
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Three-Dimensional Porous Scaffolds Derived from Bovine Cancellous Bone Matrix Promote Osteoinduction, Osteoconduction, and Osteogenesis: A. Malagón-Escandón, et al.; Polymers (Basel) 13, 4390 (2021), Abstract
Discovery of a new class of integrin antibodies for fibrosis.: Zhang, J., Talukdar, S., et al.; Sci. Rep. 11, 2118 (2021), Application(s): SW – Size / Reactant(s): Human, Abstract
Discovery of A New Class of Integrin Antibodies for Fibrosis: Zhang, J., Wang, T., et al.; bioRxiv , (2020)
Polarized Entry of Human Parechoviruses in the Airway Epithelium: E. Karelehto, et al.; Front. Cell. Infect. Microbiol. 8, 294 (2018), Application(s): FUNC / Reactant(s) Human, Abstract — Full Text
A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix: L.M. Owen, et al.; Mol. Biol. Cell 28, 1959 (2017), Application(s): ICC-IF, IF / Reactant(s) Human, Abstract — Full Text
An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model.: Zhou, X., Zhang, J., et al.; Pharmacol. Res. Perspect. 5, (2017), Application(s): SW – Size / Reactant(s): Human, Mouse, Abstract
Human Menstrual Blood-Derived Mesenchymal Stem Cells as Potential Cell Carriers for Oncolytic Adenovirus: Moreno, R., Rojas, L. A., et al.; Stem Cells Int. 2017, 3615729 (2017), Abstract
MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation: Schlosser, A., Pilecki, B., et al.; Arterioscler. Thromb. Vasc. Biol. 36, 122 (2016), Abstract
Mammary-derived growth inhibitor (MDGI) interacts with integrin alpha-subunits and suppresses integrin activity and invasion: J. Nevo, et al.; Oncogene 29, 6452 (2010), Abstract
PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells: S. Tuomi, et al.; Sci. Signal. 2, ra32 (2009), Abstract — Full Text

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CD51 (human) monoclonal antibody (L230)

ALX-803-304

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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