Home Shop CD40 (mouse) monoclonal antibody (FGK45) (biotin conjugate)

CD40 (mouse) monoclonal antibody (FGK45) (biotin conjugate)

ALX-805-046B

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Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

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This antibody is covered by our Worry-Free Guarantee.

GM8G5 hybridoma supernatant was tested on all CEACAM transfectants. A positive signal was obtained only with CEACAM1 transfected cells (purple curve)." — GM8G5 hybridoma supernatant was tested on all CEACAM transfectants. A positive signal was obtained only with CEACAM1 transfected cells (purple curve).”

Product Details

Alternative Name	TNFRSF 5
Application	ELISA, Flow Cytometry
Clone	FGK45
Formulation	Liquid. In sterile PBS.
Host	Rat
Immunogen	Recombinant mouse CD40 fusion protein.
Isotype	IgG2a
Purity Detail	Protein G-affinity purified.
Source	Purified from hybridoma tissue culture supernatant
Species Reactivity	Mouse
UniProt ID	P27512
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Do not freeze. Protect from light.
Short Term Storage	+4°C
Long Term Storage	+4°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Multivalent porous silicon nanoparticles enhance the immune activation potency of agonistic CD40 antibody: Gu, L., Ruff, L. E., et al.; Adv. Mater. 24, 3981 (2012), Abstract
Agonistic Anti-CD40 Antibody Profoundly Suppresses the Immune Response to Infection with Lymphocytic Choriomeningitis Virus: C. Bartholdy, et al.; J. Immunol. 178, 1662 (2007), Abstract
In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN: J.A. Greene, et al.; J. Immunol. 176, 5995 (2006), Abstract
IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling: P.W. Hellings, et al.; J. Immunol. 177, 5138 (2006), Abstract
IRF-7 is the master regulator of type-I interferon-dependent immune responses: K. Honda, et al.; Nature 434, 772 (2005), Abstract
CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes: C.M. McGregor, et al.; PNAS 101, 9345 (2004), Abstract — Full Text
Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system: A. Erlebacher, et al.; J. Clin. Invest. 114, 39 (2004), Abstract — Full Text
Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells: J.G. Turner, et al.; J. Immunol. 166, 89 (2001), Abstract
Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process: C. Mauri, et al.; Nat. Med. 6, 673 (2000), Abstract
Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity: A.G. Rolink, et al.; Eur. J. Immunol. 28, 3738 (1998), Abstract