Home Shop CD40 (mouse) monoclonal antibody (FGK45)

CD40 (mouse) monoclonal antibody (FGK45)

ALX-805-046

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Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

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This antibody is covered by our Worry-Free Guarantee.

Product Details

Alternative Name	TNFRSF 5
Application	ELISA, Flow Cytometry, FUNC, WB
Application Notes	Functional Application: activates B and NK cells in vivo and in vitro.
Clone	FGK45
Formulation	Liquid. In PBS containing 0.02% sodium azide.
Host	Rat
Immunogen	Recombinant mouse CD40 fusion protein.
Isotype	IgG2a
Purity Detail	Protein G-affinity purified.
Source	Purified from hybridoma tissue culture supernatant.
Species Reactivity	Mouse
UniProt ID	P27512
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2: T. Nguyen, et al.; J. Exp. Med. 220, e20221020. (2023), Abstract
Regulation of B cell functions by S-nitrosoglutathione in the EAE model.: Singh, I., Khan, M., et al.; Redox Biol. 45, 102053 (2021), Reactant(s): Mouse, Abstract
Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction: Li, X., Gadzinsky, A., et al.; Immunity 48, 530 (2018), Abstract
Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers: Lee-Chang, C., Bodogai, M., et al.; J. Immunol. 196, 3385 (2016), Abstract
Gut Microbial Metabolites Fuel Host Antibody Responses: Kim, M., Qie, Y., et al.; Cell Host Microbe 20, 202 (2016), Abstract
ATAD5 deficiency decreases B cell division and Igh recombination: K.J. Zanotti, et al.; J. Immunol. 194, 32 (2015), Abstract
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection: Chapman, J. R., Barral, P., et al.; Mol. Cell 49, 858 (2013), Abstract
CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema: A. Shigeta, et al.; Am. J. Physiol. Lung Cell. Mol. Physiol. 303, L141 (2012), Abstract — Full Text
Suppression of immune responses by nonimmunogenic oligodeoxynucleotides with high affinity for high-mobility group box proteins (HMGBs): H. Yanai, et al.; PNAS 108, 11542 (2011), Abstract — Full Text
Restricted aeroallergen access to airway mucosal dendritic cells in vivo limits allergen-specific CD4+ T cell proliferation during the induction of inhalation tolerance: V.S. Fear, et al.; J. Immunol. 187, 4561 (2011), Abstract — Full Text