CD22 Recombinant monoclonal antibody (hL22) (Rabbit IgGκ)

B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14, Epratuzumab

Flow Cytometry, FUNC, IP

hL22

Liquid. In PBS containing 0.02% Proclin 300.

Rabbit

This antibody was prepared by the humanization of LL2 (EPB-2), a murine anti-CD22 IgG2a raised against Raji Burkitt lymphoma cells. Murine sequences comprise 5–10% of the molecule, with the remainder being human framework sequences, which greatly reduces the potential for immunogenicity.

IgGκ

Protein A affinity purified.

Cynomolgus, Human, Rhesus monkey

Recognizes the 3rd Ig-like domain of human CD22 (epitope B), a cell surface glycoprotein present on mature B-cells and on many types of malignant B-cells.

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

P20273

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