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CD202B, also known as TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. TEK signaling is necessary for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.
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As a result of glycosylation, the recombinant protein migrates as an approximately 122.2 kDa and 59.5 kDa protein in SDS-PAGE under reducing conditions.
| Regulatory Status |
RUO – Research Use Only |
|---|