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Biologically active CD137L (4-1BBL; TNFSF 9) comprising the whole extracellular tail domain (aa 49-93), which is important for the cross-linking of the protein that is essential for its biological activity.
The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.
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Figure: Dose-dependent binding of recombinant human soluble CD137L to CD137:Fc (human). Recombinant human CD137L saturates its receptor at a concentration range of 2-4’000ng/ml. Method: Receptor binding assay: a 96-well ELISA plate was coated O/N with 50ng per well of CD137 (human):Fc (human) (rec.) (4-1BB:Fc) (Prod. No. ALX-522-031). After a blocking step, the indicated concentrations of rhsCD137L were added for 1 hour. After extensive washing, Enhancer for Ligands (Prod. No. ALX-804-034) was added for 1 hour. Bound ligand was revealed by a rabbit anti-mouse IgG-HRP (1:1’000 dilution
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RUO – Research Use Only |
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