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CCR4 (mouse) polyclonal antibody

ALX-210-621

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Mouse CCR4 is the homolog of human CCR4 receptor (85% identical), binding macrophage inflammatory protein-1α (MIP-1α) and RANTES. Mouse CCR4 transcripts are expressed in the thymus and in T-cell lines.

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This antibody is covered by our Worry-Free Guarantee.

CCR4 (mouse) polyclonal antibody Immunohistochemistry — **Figure:** Immunohistochemistry on paraffin section of mouse spleen with CCR4 (mouse), pAb (Prod. No. ALX-210-621).

Product Details

Alternative Name	C-C chemokine receptor 4, CD194
Application	ELISA, Flow Cytometry, ICC, IHC (PS), WB
Crossreactivity	Does not cross-react with human CCR4.
Formulation	Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
Host	Goat
Immunogen	Synthetic peptide corresponding to aa 8-26 (D8TTQDETVYNSYYFYESMP26C) of the N-terminal extracellular domain of mouse CCR4 (C-C chemokine receptor 4).
Purity Detail	Epitope-affinity purified F(ab`)2 fragment.
Quality Control	Immunocytochemistry on mouse spleen cells.
Recommendation Dilutions/Conditions	ELISA (1:100,000)Flow Cytometry (1-3µl per 2×105 cells per 50µl)Immunocytochemistry (1:500)Immunohistochemistry (1:500)Western Blot (1:1,000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Mouse
UniProt ID	P51680
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

CD4+CD25+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype: Z. Guo, et al.; Int. Immunol. 20, 307 (2008), Application(s): Flow cytometry, Abstract
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge: S.A. Khader, at al.; Nat. Immunol. 8, 369 (2007), Application(s): Flow cytometry, Abstract
CC-chemokine ligand 17 gene therapy induces tumor regression through augmentation of tumor-infiltrating immune cells in a murine model of preexisting CT26 colon carcinoma: N. Kanagawa, et al.; Int. J. Cancer 121, 2013 (2007), Application(s): Flow cytometry, Abstract
Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts: J.C. Ochando, et al.; Nat. Immunol. 7, 652 (2006), Application(s): Flow cytometry, Abstract
Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development: Y. Morimoto, et al.; J. Leukoc. Biol. 78, 753 (2005), Application(s): Flow cytometry, Abstract
Role of CCR4 ligands, CCL17 and CCL22, during Schistosoma mansoni egg-induced pulmonary granuloma formation in mice: C. Jakubzick, et al.; Am. J. Pathol. 165, 1211 (2004), Application(s): Immunohistochemistry, Abstract — Full Text
Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4: A. Hoogewerf, et al.; BBRC 218, 337 (1996), Abstract

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CCR4 (mouse) polyclonal antibody

ALX-210-621

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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