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Caveolin-1 scaffolding domain peptide

ALX-153-064

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Cell permeable eNOS blocker

Cell permeable peptide that blocks eNOS (NOS III) activity and cellular nitric oxide (NO) release in vitro and reduces inflammation and tumorigenesis in vivo. Caveolin-1 interacts with several lipid-modified signalling ligands, such as EGFR, eNOS, G-protein α-subunits, PKCα, H-Ras, and Src, via the C1-SD82-101 sequence.

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Product Details

Alternative Name	Cavtratin, AP-Cav, Pen-C1-SD
Appearance	White lyophilized powder.
Formula	C₂₂₈H₃₃₅N₆₁O₄₉S
MW	4746.6
Purity	≥97% (HPLC)
Sequence	H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH
Solubility	Soluble in DMSO or acetonitrile:water (50:50).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 3 months when stored at -20°C.
Handling	Protect from light. Hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Protective role of Cav-1 in pneumolysin-induced endothelial barrier dysfunction: R.K. Batori, et al.; Front. Immunol. 13, 945656 (2022), Abstract
Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia: D. Passaro, et al.; Cancer Cell 32, 324 (2017), Abstract — Full Text
Caveolin-1 regulates expression of junction-associated proteins in brain microvascular endothelial cells: L. Song, et al.; Blood 109, 1515 (2007), Abstract
Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides: P.N. Bernatchez, et al.; PNAS 102, 761 (2005), Abstract — Full Text
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion: T.M. Williams, et al.; J. Biol. Chem. 279, 51630 (2004), Abstract — Full Text
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice: J.P. Gratton, et al.; Cancer Cell 4, 31 (2003), Abstract
In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation: M. Bucci, et al.; Nat. Med. 6, 1362 (2000), Abstract — Full Text
Caveolins, a family of scaffolding proteins for organizing preassembled signaling complexes” at the plasma membrane”””: T. Okamoto, et al.; J. Biol. Chem. 273, 4519 (1998), Abstract — Full Text

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Caveolin-1 scaffolding domain peptide

ALX-153-064

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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