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Cathepsin L (human liver), (purified)

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Cathepsin L is a lysosomal protease that can also be secreted from the cell and is involved in protein degradation, arthritis, and cancer.

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Application Notes	Useful for inhibitor screening, kinetic studies, and cleavage of substrates in vitro or in tissue culture.
Purity	≥95% by SDS-PAGE
Source	Isolated from human liver. Negative for HbsAg, anti-HBc, anti-HCV, and anti-HIV-1 and -2.
UniProt ID	P07711 (cathepsin L1)

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs: J. Breidenbach, et al.; J. Med. Chem. 67, 8757 (2024), Abstract
Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity: P. Flury, et al.; ACS Pharmacol. Transl. Sci. 7, 493 (2024), Abstract
Predicting the Relative Binding Affinity for Reversible Covalent Inhibitors by Free Energy Perturbation Calculations: V. Bonatto, et al.; J. Chem. Inf. Model 61, 4733 (2021), Abstract
Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V: K. Bollavaram, et al.; Protein Sci. 30, 1131 (2021), Abstract
Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem. 85, 505 (2019), Application(s): Activity assay, Abstract
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract

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