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Cathepsin D (human liver), (purified)

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Cathepsin D is a lysosomal protease that can also be secreted from the cell and is involved in protein degradation, apoptosis, and cancer.

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Application Notes	Useful for inhibitor screening, kinetic studies, and cleavage of substrates in vitro or in tissue culture.
Formulation	Lyophilized with phosphate buffer.
Purity	≥95% (SDS-PAGE)
Reconstitution	Reconstitute just before first use with original volume of water.
Source	Isolated from human liver.
UniProt ID	P07339

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquotes and store at -80°C.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: Implications for Alzheimer disease pathogenesis: H.M. Terron, et al.; Alzheimers Res. Ther. 16, 70 (2024), Abstract
Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40: C.N. Suire, et al.; Alzheimers Res. Ther. 12, 80 (2020), Abstract — Full Text
Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of α-synuclein in multiple system atrophy: A.P. Kiely, et al.; Neuropathol. Appl. Neurobiol. 45, 347 (2019), Abstract
Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem. 85, 505 (2019), Application(s): Activity assay, Abstract
Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium: F.H. Al-Awadhi, et al.; Bioorg. Med. Chem. 24, 3276 (2016), Application(s): In vitro protease inhibition assays, Abstract
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract
Development of cell-active non-peptidyl inhibitors of cysteine cathepsins: D. Dana, et al.; Bioorg. Med. Chem. 21, 2975 (2013), Abstract

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