Home Shop Cathepsin B (human liver), (purified)

Cathepsin B (human liver), (purified)

BML-SE198

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Highly pure lysosomal protease

Cathepsin B is a lysosomal protease (endopeptidase and dipeptidyl carboxypeptidase) that can also be secreted from the cell and is involved in protein degradation, apoptosis, arthritis, cancer, and Alzheimer’s disease.

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Product Details

Application Notes	Useful for inhibitor screening, kinetic studies and cleavage of substrates in vitro or in tissue culture.
Formulation	Liquid. In 50mM sodium acetate, pH 5.0, containing 1mM EDTA.
MW	~27.5 kDa
Purity	≥95% (SDS-PAGE)
Source	Purified from human liver.
UniProt ID	P07858

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Human 20S Proteasome Inhibitors: Extension to the Prime Site: S.E. Border, et al.; ACS Omega 10, 31549 (2025), Abstract
MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis: Liu, S., Perez, P., et al.; Cell Death Differ. 31, 40 (2024), Abstract
Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs: J. Breidenbach, et al.; J. Med. Chem. 67, 8757 (2024), Abstract
An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans: Z. Matoušková, et al.; Int. J. Mol. Sci. 25, 2240 (2024), Abstract
Harnessing protein sensing ability of electrochemical biosensors via a controlled peptide receptor-electrode interface: J.H. Kim, et al.; J. Nanobiotechnology 21, 100 (2023), Abstract
An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily: M. Busa, et al.; J. Biol. Chem. 299, 102970 (2023), Abstract
Stimuli-responsive theranostic system: A promising approach for augmented multimodal imaging and efficient drug release: A. Demiral, et al.; Eur. J. Pharm. Biopharm. 177, 9 (2022), Abstract
Clickable, selective, and cell-permeable activity-based probe of human cathepsin B – Minimalistic approach for enhanced selectivity: A.I. Bhuiyan, et al.; Bioorg. Chem. 117, 105463 (2021), Abstract
Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V: K. Bollavaram, et al.; Protein Sci. 30, 1131 (2021), Abstract
Endosomal disentanglement of a transducible artificial transcription factor targeting endothelin receptor A: C.C. Bippes, et al.; Mol. Ther. 1525, 473 (2021), Abstract