Home Shop Caspase-7 (human), (recombinant)

Caspase-7 (human), (recombinant)

BML-SE177

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Caspase-7 acts as an effector caspase in apoptosis and has substrate preferences similar to caspase-3. It displays an affinity for ADP-ribose polymers and automodification of PARP-1 (ADP-ribosylation) makes it a better caspase-7 substrate.

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Product Details

Activity	100 U/µl
Alternative Name	Mch3, CMH-1
Application Notes	Useful tool to study enzyme regulation and kinetics, cleave target substrates, screen for inhibitors.
Formulation	Liquid. In 50mM HEPES, pH 7.4, containing 100mM sodium chloride, 0.5% CHAPS, 1mM EDTA, 10% glycerol and 10mM DTT.
MW	~20 + 12kDa
Purity	≥95% (SDS-PAGE)
Source	Produced in E. coli. Human caspase-7 (aa 24-303). Genbank Accession No. U40281.
Specific Activity	One U=1 pmol/min at 30°C using Ac-DEVD-pNA (200µM; Prod. No. ALX-260-033) as substrate.
UniProt ID	P55210

Handling & Storage

Use/Stability	After initial defrost, aliquot product into individual tubes and refreeze at -80°C. Avoid repeated freeze/defrost cycles.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases: C.M. Bourne, et al.; bioRxiv , 02.23.639785 (2025), Abstract — Full Text
Development of caspase-3-selective activity-based probes for PET imaging of apoptosis: L. Lauwerys, et al.; EJNMMI Radiopharm. Chem. 9, 58 (2024), Abstract
GSDMEa-mediated pyroptosis is bi-directionally regulated by caspase and required for effective bacterial clearance in teleost: H. Xu, et al.; Cell Death Dis. 13, 491 (2022), Abstract
A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C: R. Mintzer, et al.; PLoS One 7, e30376 (2012), Abstract — Full Text
Functional and biochemical characterization of the baculovirus caspase inhibitor MaviP35: I.L. Brand, et al.; Cell Death Dis. 2, e242 (2011), Abstract — Full Text