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Caspase-3 (human), (recombinant)

BML-SE169

14 citations

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The major effector caspase of apoptosis, caspase-3 is responsible for cleavage of multiple cellular targets.

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Product Details

Activity	100 U/µl
Alternative Name	CPP32, Yama, Apopain
Application Notes	Can be used to study enzyme regulation and kinetics, cleave target substrates and screen for inhibitors.
Formulation	Liquid. In 50mM HEPES, pH 7.4, 100mM sodium chloride, 0.5% CHAPS, 1mM EDTA, 10% glycerol and 10mM dithiothreitol.
MW	17 + 12 kDa
Purity	≥95% (SDS-PAGE)
Source	Produced in E. coli. Caspase-3 (CPP32; Yama; apopain) from human cDNA. The enzyme was cleaved and activated from the proenzyme
Specific Activity	One U=1 pmol/min using Ac-DEVD-pNA (200 µM; Prod. No. ALX-260-033) as substrate at 30°C
UniProt ID	P42574

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases: C.M. Bourne, et al.; bioRxiv , 02.23.639785 (2025), Abstract — Full Text
Development of caspase-3-selective activity-based probes for PET imaging of apoptosis: L. Lauwerys, et al.; EJNMMI Radiopharm. Chem. 9, 58 (2024), Abstract
Conjunctival epitheliopathy induced by topical exposure to bacterial peptidoglycan, muramyl dipeptide: M.P. Langford, et al.; Exp. Eye Res. 227, 109383 (2023), Abstract
Caspase-10 affects the pathogenesis of primary biliary cholangitis by regulating inflammatory cell death: M. Cho, et al.; J. Autoimmun. 133, 102940 (2022), Abstract
Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound: Ehrnhoefer, D. E., Skotte, N. H., et al.; Cell Chem. Biol. 26, 1295 (2019), Abstract
Enzyme-triggered compound release by using functionalized derivatives using antimicrobial peptide: S. Mizukami, et al.; Chem. Sci. 8, 3047 (2017), Abstract — Full Text
Approaches to design non-covalent inhibitors for human granzyme B (hGrB): M.S. Kim, et al.; Org. Biomol. Chem. 12, 8952 (2014), Abstract
Propeptide-mediated inhibition of cognate gingipain proteinases: N.L. Huq, et al.; PLoS One 8, e65447 (2013), Abstract
Vulnerable windows for developmental ethanol toxicity in the Japanese medaka fish (Oryzias latipes): S.L. Oxendine, et al.; Aquat. Toxicol. 80, 396 (2006), Abstract
Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor: K. Wheaton, et al.; Mol. Cell Biol. 24, 7298 (2004), Abstract — Full Text

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Caspase-3 (human), (recombinant)

BML-SE169

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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SDS

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