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Caspase-2 monoclonal antibody (11B4)

ALX-804-356

28 citations

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This antibody is covered by our Worry-Free Guarantee.

Caspase-2 monoclonal antibody (11B4) Western Blot — **Figure:** Detection of procaspase-2 (p51), an intermediate cleavage product of caspase-2 (p32) and activated caspase-2 (p19) in FDC-P1 cells (mouse IL-3 dependent promyelocytic line) during growth factor withdrawal induced apoptosis. Activation of caspase-2 is inhibited in the presence of the caspase inhibitor Z-VAD-FMK (ALX-260-020 or ALX-260-138 (Ready-to-Use)).”””””

Product Details

Application	IP, WB
Application Notes	Detects bands of ~51kDa (procaspase-2), ~32kDa and ~18kDa (cleavage products) by Western blot. For FC, ICC and IHC (FS) use MAb to Caspase-2 (10C6) (Prod. No. ALX-804-355).
Clone	11B4
Formulation	Liquid. In PBS containing 0.02% sodium azide.
Host	Rat
Immunogen	Recombinant human caspase-2 p19 fragment.
Isotype	IgG2a
Purity Detail	Protein G-affinity purified.
Recommendation Dilutions/Conditions	Western Blot (2µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Dog, Human, Monkey, Mouse, Rat
Specificity	Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2. Detects bands of ~51kDa (procaspase-2), ~32kDa and ~18kDa (cleavage products) by Western blot.
UniProt ID	P42575
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics.: Bosc, E., Anastasie, J., et al.; Cell Death Dis. 13, 959 (2022), Application(s): WB, Abstract
Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells: D.D. Pham, et al.; Cell Death Dis. 10, 537 (2019), Abstract — Full Text
Taxane-mediated radiosensitization derives from chromosomal missegregation on tripolar mitotic spindles orchestrated by AURKA and TPX2: M. Orth, et al.; Oncogene 37, 52 (2018), Abstract — Full Text
ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P: J.Y. Kim, et al.; Cell 175, 133 (2018), Abstract
Cleavage of Ku80 by caspase-2 promotes non-homologous end joining-mediated DNA repair: Q. Yan, et al.; DNA Repair (Amst.) 60, 18 (2017), Abstract
Differing Mechanisms of Death Induction by Fluorinated Taxane SB-T-12854 in Breast Cancer Cells: K. Jelinek, et al.; Anticancer Res. 37, 1581 (2017), Application(s): WB / Reactant(s) Human, Abstract
The DEAD-box RNA helicase DDX41 is a novel repressor of p21WAF1/CIP1 mRNA translation: D. Peters, et al.; J. Biol. Chem. 292, 8331 (2017), Abstract — Full Text
Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment: Lopez-Cruzan, M., Sharma, R., et al.; Cell Death Discov. 2, (2016), Abstract
Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice: A. Venkatesh, et al.; J. Clin. Invest. 124, 1446 (2015), Abstract — Full Text
An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death: M. Garcia-Belinchon, et al.; J. Biol. Chem. 290, 20841 (2015), Abstract — Full Text

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Caspase-2 monoclonal antibody (10C6)

ALX-804-355

6 citations

Application	ELISA, Flow Cytometry, ICC, IHC (FS)
Host	Rat
Isotype	IgG2a
Species Reactivity	Dog, Human, Monkey, Mouse, Rat

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Caspase-2 monoclonal antibody (11B4)

ALX-804-356

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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