Home Shop Caspase-2 monoclonal antibody (10C6)

Caspase-2 monoclonal antibody (10C6)

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This antibody is covered by our Worry-Free Guarantee.

Application	ELISA, Flow Cytometry, ICC, IHC (FS)
Clone	10C6
Formulation	Liquid. In PBS containing 0.02% sodium azide.
Host	Rat
Immunogen	Recombinant human caspase-2 (p19 subunit).
Isotype	IgG2a
Purity Detail	Protein G-affinity purified.
Recommendation Dilutions/Conditions	Flow Cytometry (1µg/ml)Immunocytochemistry (10-20µg/ml; fix in 4% paraformaldehyde, 0.18% Triton-X100 for 10 min. prior to staining)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Dog, Human, Monkey, Mouse, Rat
Specificity	Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2.
UniProt ID	P42575
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Regulatory Status	RUO – Research Use Only

Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment: M. Lopez-Cruzan, et al.; Cell Death Discov. 2, 16005 (2016), Application(s): Immunocytochemistry, Abstract — Full Text
ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis: Sandow, J. J., Dorstyn, L., et al.; Cell Death Differ. 21, 475 (2014), Abstract
Caspase-2 is involved in cell death induction by taxanes in breast cancer cells.: Kovar, J., Balusikova, K., et al.; Cancer Cell Int. 13, 42 (2013), Application(s): WB / Reactant(s): Human, Abstract
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death: V.S. Marsden, et al.; Blood 107, 1872 (2006), Abstract — Full Text
Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation: C.L. Scott, et al.; J. Cell Biol. 164, 89 (2004), Abstract — Full Text
Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9: L.A. O; Cell Death Differ. 9, 832 (2002), Abstract — Full Text

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