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Caspase-11 (mouse), (recombinant)

BML-SE155

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A member of the caspase-1 subfamily, caspase-11 is the possible homolog of human caspase-4. Its expression is highly inducible, in various mouse tissues, by LPS injection.

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Caspase-11 (mouse), (recombinant) SDS-PAGE — SDS-PAGE Analysis: Lane 1: MW Marker, Lane 2: 1 μg, Lane 2: 2 μg Caspase-11.

Product Details

Activity	100 U/µl
Formulation	Liquid. In 50mM HEPES, pH 7.4, 100mM NaCl, 0.5% CHAPS, 1 mM EDTA, 10% glycerol, 10mM DTT.
MW	23 + 10 kDa subunits
Purity	≥95% (SDS-PAGE)
Source	Produced in E. coli. Mouse caspase-11 (aa 81-373).
Specific Activity	One unit hydrolyzes 1 pmol/min of Ac-WEHD-pNA (500 µM, Prod. No. ALX-260-082) at 30°C.
UniProt ID	P70343

Handling & Storage

Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases: C.M. Bourne, et al.; bioRxiv , 02.23.639785 (2025), Abstract — Full Text
The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases: Exconde, P. M., Hernandez-Chavez, C., et al.; Cell Rep. 42, 113581 (2023), Abstract
Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection: Selkrig, J., Li, N., et al.; Nat. Microbiol. 5, 1119 (2020), Abstract
Cathepsin G inhibition by serpinb1 and serpinb6 prevents programmed necrosis in neutrophils and monocytes and reduces GSDMD-driven inflammation: S.S. Burgener, et al.; Cell Rep. 27, 3646 (2019), Abstract

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Ac-WEHD-pNA

ALX-260-082

Substrate for caspase-1, -4, -5 and -14

3 citations

Purity	≥98% (HPLC)

Last modified: May 29, 2024

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Caspase-11 (mouse), (recombinant)

BML-SE155

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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