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Carnosic acid

ALX-270-264

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PPARγ activator. Antioxidant.

Naturally occurring phenolic compound with antioxidant properties. Inhibits lipid peroxidation induced by NADH or NADPH oxidation. Peroxisome proliferator-activated receptor γ (PPARγ) activator. Anti-inflammatory. Antimicrobial.

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Product Details

Appearance	Yellow powder.
CAS	3650-09-7
Couple Target	PPAR
Couple Type	Activator
Formula	C₂₀H₂₈O₄
MW	332.4
Purity	≥95% (HPLC)
Source	Isolated from Rosmarinus officinalis.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa: K. Kang, et al.; Sci. Rep. 6, 22632 (2016), Application(s): Injection into mice, Abstract — Full Text
Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells: S. Nishimoto, et al.; Toxicol. Appl. Pharmacol. 305, 161 (2016), Application(s): Nuclear transcription factor activation, Abstract
Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid: S. Pesakhov, et al.; Oncotarget 7, 31847 (2016), Abstract — Full Text
The anti-cancer effects of carotenoids and other phytonutrients resides in their combined activity: K. Linnewiel-Hermoni, et al.; Arch. Biochem. Biophys. 572, 28 (2015), Application(s): Cell Culture, Abstract
Carnosic acid protects photoreceptor against degeneration in Pde6rd10 mice through activating Nrf2 pathway: K. Kang, et al.; Acta Pharm. Sin. B , (2015), Application(s): Intraperitoneal injection to Pde6rd10 mice
Cell-Type-Specific Effects of Silibinin on Vitamin D-Induced Differentiation of Acute Myeloid Leukemia Cells Are Associated with Differential Modulation of RXRα Levels: Wassermann, R., Novik, V., et al.; Leuk. Res. Treatment 2012, 401784 (2012), Abstract
Tumor suppressor p53 status does not determine the differentiation-associated G₁ cell cycle arrest induced in leukemia cells by 1,25-dihydroxyvitamin D₃ and antioxidants: Thompson, T., Danilenko, M., et al.; Cancer Biol. Ther. 10, 344 (2010), Abstract
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis: K. Horiuchi, et al.; Biol. Pharm. Bull. 30, 287 (2007), Abstract
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma: O. Rau, et al.; Planta Med. 72, 881 (2006), Abstract
Chemiluminescence determination of the in vivo and in vitro antioxidant activity of RoseOx and carnosic acid: A.I. Kuzmenko, et al.; J. Photochem. Photobiol. B 48, 63 (1999), Abstract

Last modified: May 29, 2024

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Carnosic acid

ALX-270-264

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Handling & Storage

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