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Carbenicillin . disodium salt

ALX-380-270

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Antibiotic

Analog to ampicillin (Prod. No. ALX-380-268). Inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Effective against Gram-positive and Gram-negative bacteria and Pseudomonas.

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Product Details

Alternative Name	α-Carboxybenzylpenicillin . 2Na
Appearance	White to off-white powder.
CAS	4800-94-6
Couple Target	Transpeptidase
Couple Type	Inhibitor
Formula	C₁₇H₁₆N₂O₆S . 2Na
MI	14: 1792
MW	376.4 . 46.0
Purity	≥92% (Assay)
RTECS	ON9105000
Solubility	Soluble in water (50mg/ml).
Source	Semisynthetic from penicillin.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

New carbenicillin-hydrolyzing beta-lactamase (CARB-7) from Vibrio cholerae non-O1, non-O139 strains encoded by the VCR region of the V. cholerae genome: R. Melano, et al.; Antimicrob. Agents Chemother. 46, 2162 (2002), Abstract — Full Text
Stereoselective renal tubular secretion of carbenicillin: T. Itoh, et al.; Antimicrob. Agents Chemother. 37, 2327 (1993), Abstract — Full Text
Nucleotide sequence and characterization of a carbenicillin-hydrolyzing penicillinase gene from Proteus mirabilis: Y. Sakurai, et al.; J. Bacteriol. 173, 7038 (1991), Abstract — Full Text
In vitro susceptibility of Pseudomonas species to carbenicillin and trimethoprim-sulfamethoxazole: S.F. Hill, et al.; J. Clin. Microbiol. 22, 465 (1985), Abstract — Full Text