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Carbamyl-PAF

BML-L120

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PAF receptor activator

Biologically potent, non-metabolizable analog of platelet-activating factor (PAF). Induces half-maximal PMNL degranulation response at 16nM and binds stereospecifically to high and low affinity PAF receptors. Completely resists inactivation by acetylhydrolase.

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Product Details

Alternative Name	1-O-Hexadecyl-2-N-methylcarbamyl-sn-glycero-3-phosphocholine
Appearance	White solid.
CAS	91575-58-5
Couple Target	PAF receptor
Couple Type	Activator, Ligand
Formula	C₂₆H₅₅N₂O₇P
MW	538.7
Purity	≥98% (TLC)
Solubility	Soluble in 100% ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Ethanol stock solutions are stable for up to 3 months at -20°C. Aqueous solutions should be prepared fresh daily.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Platelet activating factor-induced expression of p21 is correlated with histone acetylation: Damiani, E., Puebla-Osorio, N., et al.; Sci. Rep. 7, 41959 (2017), Abstract
PAF-acether transfer activity in HL-60 cells is induced during differentiation: R.H. Lumb, et al.; Biochem. Biophys. Res. Commun. 171, 548 (1990), Abstract
Stimulation of platelet-activating factor synthesis by a nonmetabolizable bioactive analog of platelet-activating factor and influence of arachidonic acid metabolites: T.G. Tessner, et al.; J. Biol. Chem. 264, 4794 (1989), Abstract
1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: a biologically potent, non-metabolizable analog of platelet-activating factor: J.T. O’Flaherty, et al.; Biochem. Biophys. Res. Commun. 147, 18 (1987), Abstract

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Carbamyl-PAF

BML-L120

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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