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Cantharidin

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PP2A inhibitor

Potent protein phosphatase 2A (PP2A) inhibitor. At higher concentrations, also inhibits protein phosphatase 1 (PP1).

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Alternative Name	Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione
Appearance	White to off-white solid.
CAS	56-25-7
Couple Target	Serine/threonine-protein phosphatase
Couple Type	Inhibitor
Formula	C₁₀H₁₂O₄
MI	14: 1752
MW	196.2
Purity	≥98% (GC)
Solubility	Soluble in DMSO or 100% ethanol.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

MAP kinases associate with high molecular weight multiproteincomplexes: C.J. Bequette, et al.; J. Exp. Bot. 69, 643 (2018), Abstract — Full Text
PP2A inhibitors suppress migration and growth of PANC-1 pancreatic cancer cells through inhibition on the Wnt/β-catenin pathway by phosphorylation and degradation of β-catenin: M.Y. Wu, et al.; Oncol Rep. 32, 513 (2014), Abstract — Full Text
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues: Y.-M. Li, et al.; Biochem. Pharmacol. 46, 1435 (1993), Abstract
Cantharidin-binding protein: identification as protein phosphatase 2A: Y.-M. Li & J.E. Casida; PNAS 89, 11867 (1992), Abstract
Partial characterization of specific cantharidin binding sites in mouse tissues: M.J. Graziano, et al.; Mol. Pharmacol. 33, 706 (1988), Abstract

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