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Cantharidic acid

BML-PR106

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PP2A inhibitor

Potent and selective inhibitor of PP2A, IC₅₀=53nM (IC₅₀ for PP1=562nM). Useful for inhibiting PP1 and PP2A during purification of phosphorylated proteins.

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Product Details

Appearance	White solid.
CAS	28874-45-5
Couple Target	Serine/threonine-protein phosphatase
Couple Type	Inhibitor
Formula	C₁₀H₁₄O₅
MW	214.2
MeltingPoint	216-218°C
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml) or ethanol (10mg/ml warm).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 5 years. Store solutions at -20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

CD44 induced enhancement of phosphatase activity and calcium influx: Modifications of EGR-1 expression and cell proliferation: R.R. Racine, et al.; Biochem. Biophys. Rep. 6, 172 (2016), Application(s): Western blot and proliferation experiments, Abstract — Full Text
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues: Y.M. Li, et al.; Biochem. Pharmacol. 46, 1435 (1993), Abstract
Cantharidin-binding protein: identification as protein phosphatase 2A: Y.M. Li & J.E. Casida; PNAS 89, 11867 (1992), Abstract

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Cantharidic acid

BML-PR106

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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