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Canavanine . sulfate

ALX-350-002

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iNOS inhibitor

The non-protein amino acid L-canavanine is an analog of L-arginine. Selective inducible nitric oxide synthase (iNOS; NOS II) inhibitor. Induces apoptotic cell death and shows antiproliferative and immunotoxic effects.

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Product Details

Alternative Name	L-α-Amino-γ-(guanidinooxy)-n-butyric acid . sulfate
Appearance	White to-off white powder.
CAS	2219-31-0
Couple Target	NOS
Couple Type	Inhibitor
Formula	C₅H₁₂N₄O₃. H₂SO₄
Identity	Identity determined by IR.
MI	14: 1737
MW	176.2 . 98.1
Purity	≥99% (TLC)
Solubility	Soluble in water (100mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Role of non-protein amino acid L-canavanine in autoimmunity: J. Akaogi, et al.; Autoimmun. Rev. 5, 429 (2006), Abstract
L-arginine analogs as alternate substrates for nitric oxide synthase: S.D. Luzzi & M.A. Marletta; Bioorg. Med. Chem. Lett. 15, 3934 (2005), Abstract
Comparative effects of vasopressin, norepinephrine, and L-canavanine, a selective inhibitor of inducible nitric oxide synthase, in endotoxic shock: B. Levy, et al.; Am. J. Physiol. Heart Circ. Physiol. 287, H209 (2004), Abstract — Full Text
L-Canavanine as a radiosensitization agent for human pancreatic cancer cells: A.K. Bence, et al.; Mol. Cell Biochem. 244, 37 (2003), Abstract
Effect of L-canavanine, an Inhibitor of inducible nitric oxide synthase, on myocardial dysfunction during septic shock: N. Suzuki, et al.; J. Nippon Med. Sch. 69, 13 (2002), Abstract — Full Text
The antiproliferative and immunotoxic effects of L-canavanine and L-canaline: A.K. Bence, et al.; Anticancer Drugs 13, 313 (2002), Abstract
Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bcl-xL: M.H. Jang, et al.; BBRC 295, 283 (2002), Abstract
L-canavanine, a selective inhibitor of inducible NO synthase, increases plasma endothelin-1 concentrations in dogs with endotoxic shock: C. Mitaka, et al.; J. Crit. Care 16, 17 (2001), Abstract
Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain: H.M. Abd El-Gawad & A.E. Khalifa; Pharmacol. Res. 43, 257 (2001), Abstract
Beneficial effects of L-canavanine, a selective inhibitor of inducible nitric oxide synthase, on lactate metabolism and muscle high energy phosphates during endotoxic shock in rats: B. Levy, et al.; Shock 11, 98 (1999), Abstract

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Canavanine . sulfate

ALX-350-002

Product Details

Handling & Storage

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