Camptothecin, -9-Amino (10mM)

9-Amino-20-(R,S)-camptothecin (also known as 9-amino campthecin) is an analogue of camptothecin. Like other CPT congeners, it shows some promising activity against a range of tumour types. This compound causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks. This reagent is provided as a control poison/inhibitor of topoisomerase I.