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Synthetic peptide with sequence from Ca2+/calmodulin-dependent protein kinase II pseudosubstrate site. Peptide binds calmodulin tightly and inhibits calmodulin-requiring enzymes including CaMKII, phosphodiesterase and calcineurin. IC50=52 nM for CaMKII in the presence of 100 nM calmodulin.
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Last modified: May 29, 2024