Calpeptin

BML-PI101

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Calpain and cathepsin inhibitor

Membrane permeable inhibitor of calpain I and II, cathepsin L and cathepsin K (IC₅₀=0.11 nM). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca²⁺-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin (Prod. No. ALX-450-006) or thrombin. Inhibits LPS induced iNOS transcription and NF-κB activation, possibly via proteasome inhibition.

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Product Details

Alternative Name	Z-Leu-norleucinal, N-Benzyloxycarbonyl-L-leucyl-norleucinal
Appearance	White to off-white powder.
CAS	117591-20-5
Couple Target	Calpain, Cathepsin, Proteasome
Couple Type	Inhibitor
Formula	C₂₀H₃₀N₂O₄
MW	362.5
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml or dimethyl formamide (5mg/ml).
Technical Info / Product Notes	Concentrations for intact cells: 30µM (platelets), 10µM (myoblast cells) Note: Product is not sterile.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for up to 1 year when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light and moisture. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Simvastatin reduces the carcinogenic effect of 3-methylcholanthrene in renal epithelial cells through histone deacetylase 1 inhibition and RhoA reactivation: C.C. Chang, et al.; Sci. Rep. 9, 4606 (2019), Abstract — Full Text
The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin: L.C. Burzynski, et al.; Immunity 50, 1033 (2019), Abstract
Effect and mechanism of calpains on pediatric lobar pneumonia: Yin, G., Zeng, Q., et al.; Bioengineered 8, 374 (2017), Abstract
Human normal bronchial epithelial cells: a novel in vitro cell model for toxicity evaluati: W. Feng, et al.; PLoS One 10, e0123520 (2015), Application(s): Cell Culture, Abstract — Full Text
Effect of SI-591, a new class of cathepsin K inhibitor with peptidomimetic structure, on bone metabolism in vitro and in vivo: T. Fujii, et al.; Bone 81, 427 (2015), Application(s): Human and Rat Cathepsin K assays, Abstract
Membrane-Permeable Calpain Inhibitors Promote Rat Oral Mucosal Epithelial Cell Proliferation by Inhibiting IL-1α Signaling: M. Kondo, et al.; PLoS One 10, e0134240 (2015), Application(s): Cell culture, Abstract — Full Text
P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism: Al-Bahlani, S., Fraser, M., et al.; Oncogene 30, 4219 (2011), Abstract
Exploration of the P1 SAR of aldehyde cathepsin K inhibitors: J.G. Catalano, et al.; Bioorg. Med. Chem. Lett. 14, 275 (2004), Abstract
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B: J.M. Griscavage, et al.; PNAS 93, 3308 (1996), Abstract — Full Text
Endogenous cleavage of phospholipase C-beta 3 by agonist-induced activation of calpain in human platelets: Y. Banno, et al.; J. Biol. Chem. 270, 4318 (1995), Abstract

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32 citations

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Purity	≥90% (HPLC, TLC)

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Calpeptin

BML-PI101

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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