Home Shop Calnexin monoclonal antibody (AF18)

Calnexin monoclonal antibody (AF18)

ALX-804-014

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Calnexin, also referred to as IP90 or p88, is a ~88kDa chaperone protein found in the endoplastmic reticulum. It binds with partially folded immunoglobulin proteins and retains them in the endoplastmic reticulum until they are completely folded.

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Product Details

Alternative Name	p88, IP90
Application	ICC, IP, WB
Application Notes	Detects a band of ~90kDa by Western blot.
Clone	AF18
Formulation	Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
Host	Mouse
Immunogen	Focus human hepatoma cell line.
Isotype	IgG1
Recommendation Dilutions/Conditions	Immunocytochemistry (1:500)Immunoprecipitation, Western Blot (1:4,000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human, Mouse
UniProt ID	P27824
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects.: Bird, T. D., Freisinger, P., et al.; J. Exp. Med. 214, 3707 (2017), Application(s): ICC-IF, IF / Reactant(s): Human, Abstract
VAP (VAMP-Associated Proteins) as Receptors that couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis: W.L. Ernst, et al.; J. Biol. Chem. 291, 5206 (2016), Application(s): Cell culture, Abstract — Full Text
A Versatile Method for Immunofluorescent Staining of Cells Cultured on Permeable Membrane Inserts.: Taylor, J. M., Marlin, J. W., et al.; Med. Sci. Monit. Basic Res. 22, 91 (2016), Reactant(s): Human, Abstract
Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance: Bekele, R. T., Venkatraman, G., et al.; Sci. Rep. 6, 21164 (2016), Abstract
Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles: Cheret, C., Willem, M., et al.; EMBO J. 32, 2015 (2013), Abstract
Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis: H. Zhang, et al.; J. Biol. Chem. 281, 11312 (2006), Abstract — Full Text
The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma: K.T. Chin, et al.; Nucl. Acids Res. 33, 1859 (2005), Abstract — Full Text
The stop transfer sequence of the human UDP-glucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms: L. Barre, et al.; Febs J. 272, 1063 (2005), Abstract — Full Text
Transient calnexin interaction confers long-term stability on folded K+ channel protein in the ER: R. Khanna, et al.; J. Cell Sci. 117, 2897 (2004), Abstract — Full Text
An LQT mutant minK alters KvLQT1 trafficking: A. Krumerman, et al.; Am. J. Physiol. Cell Physiol. 286, C1453 (2004), Abstract

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Calnexin monoclonal antibody (AF18)

ALX-804-014

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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