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Calmodulin (human), (recombinant)

BML-SE325

14 citations

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Calcium-binding protein produced in E.coli

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Calmodulin (human), (recombinant) activation — Human recombinant calmodulin (Prod. No. BML-SE325) activation of human calcineurin is essentially identical to that of purified bovine brain calmodulin (native, bovine). Initial rates of calcineurin phosphatase activity were determined as a function of calmodulin concentration with the Calcineurin Colorimetric Drug Discovery Kit (Prod. No. BML-AK804). (Note that the human and bovine calmodulin amino acid sequences are 100% identical.)

Calmodulin (human), (recombinant) SDS-PAGE — SDS-PAGE Analysis: Lane 1: MW Marker; Lane 2: 1.0 µg of purified human recombinant calmodulin protein (Prod. No. BML-SE325).

Product Details

Alternative Name	CaM, Phosphodiesterase 3′:5′-cyclic nucleotide activator
Application Notes	Calmodulin can be used to activate calmodulin-dependent phosphodiesterase, calcineurin, CaM kinases, etc.
Biological Activity	Elicits Ca²⁺-dependent activation of calcineurin (Ca²⁺/calmodulin-dependent Ser/Thr protein phosphatase 2B, PP-2B) with the same potency and to the same maximum extent as purified native calmodulin.
CAS	73298-54-1
Formulation	Lyophilized. Salt-free.
MI	14: 1719
MW	16.8 kDa
Purity	≥95% (SDS-PAGE)
Purity Detail	Purified by multi-step chromatography.
Reconstitution	Reconstitute in water or an appropriate buffer.
Sequence	Sequence identical to Genbank accession M27319.1.
Source	Produced in E. coli.
UniProt ID	P62158

Handling & Storage

Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer: Yang, X., Ma, X., et al.; Nat. Commun. 16, 1871 (2025), Abstract
Development of a monoclonal antibody specific for a calpain-generated Δ48 kDa calcineurin fragment, a marker of distressed astrocytes: S.D. Kraner, et al.; J. Neurosci. Methods 402, 110012 (2024), Abstract
Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically ‘actionable’ signalling axis in triple negative breast cancer: Yang, X., Ma, X., et al.; bioRxiv , (2024)
Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity: I. Barone, et al.; Sci. Adv. 9, eadj1010 (2023), Abstract
1D continuous gel electrophoresis composition for the separation of deamidated proteins: Boudier-Lemosquet, A., Mahler, A., et al.; Methods 200, 23 (2022), Abstract
Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks: Delint-Ramirez, I., Konada, L., et al.; Mol. Cell 82, 3794 (2022), Abstract
NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly: T. Niu, et al.; Nat. Commun. 12, 5862 (2021), Abstract
Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel: Bhardwaj, R., Augustynek, B. S., et al.; Cell. Physiol. Biochem. 54, 252 (2020), Abstract
Paxillin-Mediated Recruitment of Calcineurin to the Contractile Ring Is Required for the Correct Progression of Cytokinesis in Fission Yeast: R. Martin-Garcia, et al.; Cell Rep. 25, 772 (2018), Abstract
Correction: A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain ‘Slots’ in the postsynaptic density: W.G. Walkup, et al.; Elife 5, e22495 (2016), Application(s): Measurement of affinity of CaM for r-synGAP-a1 by SPR, Abstract — Full Text

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Calmodulin (human), (recombinant)

BML-SE325

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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