Calcitonin gene related peptide polyclonal antibody

Calcitonin gene-related peptide (CGRP) is a 37-amino acid disulphide-bridged sensory neuropeptide present in the central and peripheral nervous systems of many animal species. Two forms of CGRP (α and β) have been identified from both rat and human, and the sequence of chicken CGRP has also been reported, showing striking structural similarity to the mammalian forms. CGRP is abundant in perivascular sensory neurons and is known to be a potent vasodilator. Recent work supports the rôle of CGRP in mediating skin vasodilatation and differential mesenteric artery vasorelaxation, as well as serving as an endogenous myocardial protective substance with a possible involvement in the inhibition of human platelet aggregation. CGRP is frequently co-localised with Substance P and immunoelectron microscopic observations have shown that the peptides are co-stored in single secretory granules both in sensory neurons and in thyroid C-cells. There are many hundreds of reports in the scientific literature describing the localisation and co-existence of CGRP with other transmitter molecules in a vast array of mammalian and non-mammalian species.