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GST activator

Inducer of glutathione S-transferases. Has chemoprotective activity, reducing the genotoxicity of several carcinogens.

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Appearance	White to off-white solid.
CAS	469-83-0
Couple Target	GST
Couple Type	Activator
Formula	C₂₀H₂₈O₃
MI	14: 1634
MW	316.4
Purity	≥98% (UHPLC)
Solubility	Soluble in DMSO, 100% ethanol or ethyl acetate.
Source	Isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity: C. Cavin, et al.; Food Chem. Toxicol. 40, 1155 (2002), Abstract
The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism: C. Cavin, et al.; Carcinogenesis 19, 1369 (1998), Abstract
Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse: L.K. Lam, et al.; Cancer Res. 42, 1193 (1982), Abstract
Zur Chemie des Kaffees, IV. Mitteil.: Zur Konstitutionsaufklärung des Cafesterols: K.H. Slotta & K. Neisser; Ber. dtsch. chem. Ges. 71, 1991 (1938)
The chemistry of the coffee-bean: I. Concerning the unsaponifiable matter of the coffee-bean oil. Preparation and properties of kahweol: R.O. Bengis & R.J. Anderson; J. Biol. Chem. 97, 99 (1932), Full Text

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