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Cabozantinib

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Potent inhibitor of VEGFR-2, MET, Kit and FLT3-ITD

Cabozantinib is a very potent inhibitor, with an IC₅₀ of less than 10 nM for VEGFR2, MET, Kit and FLT3-ITD.

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Alternative Name	XL184, BMS-907351, N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Appearance	Off-white to white powder.
CAS	849217-68-1
Couple Target	c-Kit, Flt, MET, VEGFR
Couple Type	Inhibitor
Formula	C₂₈H₂₄FN₃O₅
Identity	Determined by NMR.
MW	501.5
Purity	≥99% (HPLC)
Solubility	Soluble in DMSO (100mg/ml) or ethanol (1mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Last modified: May 29, 2024

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