CA-074

ALX-260-017

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Cathepsin B inhibitor

Potent and specific inhibitor of cathepsin B in vitro and in vivo. Free acid form used in vitro or in isolated enzyme studies but not in whole cells. Can discriminate between cathepsin B and L/S forms.

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Product Details

Alternative Name	N-[L-3-trans-Propylcarbamoyloxirane-2-carbonyl]-Ile-Pro-OH
Appearance	White to off-white powder.
CAS	134448-10-5
Formula	C₁₈H₂₉N₃O₆
MW	383.5
Purity	≥98% (HPLC)
Solubility	Soluble in ethyl acetate (50mg/ml) or DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Fluorometric microassays for the determination of cathepsin L and cathepsin S activities in tissue extracts: B. Werle, et al.; Biol. Chem. 380, 1109 (1999), Abstract
Specific assay method for the activities of cathepsin L-type cysteine proteinases: T. Inubushi, et al.; J. Biochem. 116, 282 (1994), Abstract
Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro: M. Murata, et al.; FEBS Lett. 280, 307 (1991), Abstract
Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo: T. Towatari, et al.; FEBS Lett. 280, 311 (1991), Abstract

Last modified: May 29, 2024

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CA-074

ALX-260-017

Product Details

Handling & Storage

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