C75

ALX-270-286

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Fatty acid synthase inhibitor

Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of fatty acid synthase. Downregulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. Shows significant in vivo antitumor activity in human breast cancer cells. Suppresses DNA replication and induces apoptosis. FAS inhibition by C75 leads to a dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei.

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Product Details

Alternative Name	trans-4-Carboxy-5-octyl-3-methylene-butyrolactone
Appearance	White to off-white solid.
CAS	191282-48-1
Couple Target	Fatty acid synthase
Couple Type	Inhibitor
Formula	C₁₄H₂₂O₄
MW	254.3
Purity	≥98%
Solubility	Soluble in dichloromethane, methanol or DMSO.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Fatty acid synthase regulates estrogen receptor-α signaling in breast cancer cells: J.A. Menendez, et al.; Oncogenesis 6, e299 (2017), Abstract — Full Text
To complete its replication cycle, a shrimp virus changes the population of long chain fatty acids during infection via the PI3K-Akt-mTOR-HIF1α pathway: Y.C. Hsieh, et al.; Dev. Comp. Immunol. 53, 85 (2015), Application(s): Injection into shrimp, Abstract
Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells: Corominas-Faja, B., Cuyàs, E., et al.; Oncotarget 5, 8306 (2014), Abstract
Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity: Puig, T., Turrado, C., et al.; Clin. Cancer Res. 15, 7608 (2009), Abstract
Fatty acid synthase expression is induced by the Epstein-Barr virus immediate-early protein BRLF1 and is required for lytic viral gene expression: Li, Y., Webster-Cyriaque, J., et al.; J. Virol. 78, 4197 (2004), Abstract
C75 activates malonyl-CoA sensitive and insensitive components of the CPT system: C. Nicot, et al.; BBRC 325, 660 (2004), Abstract
Long-term effects of a fatty acid synthase inhibitor on obese mice: food intake, hypothalamic neuropeptides, and UCP3: S.H. Cha, et al.; BBRC 317, 301 (2004), Abstract
Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells: J.A. Menendez, et al.; Oncogene 23, 4945 (2004), Abstract
C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism: L.E. Landree, et al.; J. Biol. Chem. 279, 3817 (2004), Abstract
The anorexigenic fatty acid synthase inhibitor, C75, is a non-specific neuronal activator: K.A. Takahashi, et al.; Endocrinology 145, 184 (2004), Abstract

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C75

ALX-270-286

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