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C6 Ceramide

BML-SL110

9 citations

  • BML-SL110-0005   —   5 mg
    $84.00
  • BML-SL110-0025   —   25 mg
    $378.00

A biologically active, cell-permeable, but nonphysiologic ceramide analog. It activates protein phosphatase 2A and MAP kinase (MAPK/ERK), suppresses insulin-induced tyrosine phosphorylation and inhibits glycoprotein traffic by the secretory pathway. It inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. It induces an arrest at the G0/G1 transition of the cell cycle (10μM) and causes apoptosis (15μM or greater) in Molt-4 leukemia cells.

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Regulatory Status

RUO – Research Use Only