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Cyclic oligoadenylates were found to be novel bacterial second messengers involved in the Type III CRISPR-Cas-associated detection and degradation of invasive genetic elements in many prokaryotes. The Streptococcus thermophilus type III-A CRISPR-Cas system produces c-pentaAMP as well as a range of differently sized cyclic oligoadenylates both in vitro and in vivo, although only the least abundant c-hexaAMP (Biolog Cat. No. C 332) activated the Csm6 ribonuclease of this organism.
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| Regulatory Status |
RUO – Research Use Only |
|---|
Related Products
| Alternative Name | Cyclic diadenosine monophosphate, Cyclic bis (3’→5′) diadenylic acid . disodium salt |
|---|---|
| CAS | 54447-84-6 |
| Couple Type | Modified nucleotides |
| Purity | > 98% HPLC (typically > 99%) |
| Alternative Name | Cyclic hexaadenosine monophosphate . sodium salt, Cyclic hexaadenylate, c-A6 |
|---|---|
| CAS | 232933-63-0 |
| Purity | > 95% HPLC |
| Alternative Name | Cyclic tetraadenosine monophosphate . sodium salt, Cyclic tetraadenylate, c-A4 |
|---|---|
| Purity | > 95% HPLC |
| Alternative Name | Cyclic triadenosine monophosphate . sodium salt, Cyclic triadenylate, c-A3, cOA3 |
|---|---|
| Purity | > 95% HPLC |