Home Shop C-erbB-2 (human) clonal antibody (A24-V)

C-erbB-2 (human) clonal antibody (A24-V)

ALX-810-227

8 citations

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C-erbB-2 (human) clonal antibody (A24-V) Immunohistochemistry — **Figure 1:** Formalin-fixed and paraffin-embedded human breast ductal carcinoma tissue (4μm) stained with C-erbB-2 (human), cAb (A24-V) (Prod. No. ALX-810-227) shows strong membranous immunostaining of neoplastic cells.(Kindly performed and provided by Katarína Poliaková, MD and Lubomír Straka, MD, Ph. D. from Clinical Pathology Presov, Ltd., Presov, Slovakia)

Product Details

Alternative Name	ErbB2, HER-2, NEU proto-oncogene, CD340
Application	IHC (FS), IHC (PS)
Clone	A24-V
Formulation	Liquid. In 20mM TRIS/HCl, pH 8.0, containing 20mg/ml BSA and 0.05% sodium azide.
Host	Rabbit
Immunogen	Synthetic peptide corresponding to the C-terminal region of human C-erbB-2.
Isotype	IgG
Purity Detail	Major clone of IgGs obtained from immunoaffinity purified immunoglobulins corresponding to immunogenic peptide.
Recommendation Dilutions/Conditions	Immunohistochemistry (paraffin sections, 1:100-1:300)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human
Technical Info / Product Notes	Clonal Rabbit Antibody is a pure homogenous fraction of rabbit immunoglobulin (IgG) which corresponds to a unique linear epitope on the target protein. This epitope is designed after a detailed analysis of the antigen structure, regulatory post-translational modifications, protein/protein interaction domain and protein folding. The chosen sequence (peptide) is synthesized and the rabbit is immunized. The clone is then separated from the crude antiserum by “in vitro cloning technology”. The resulting product is monospecific and characterized by superior specificity, affinity and avidity.
UniProt ID	P04626
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Use/Stability	Stable for at least 12 months after receipt when stored as recommended.
Handling	After opening, prepare aliquots and store at +4°C.
Long Term Storage	+4°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

EGFR-directed antibodies promote HER2 ADC internalization and efficacy: Gupta, A., Michelini, F., et al.; Cell Rep. Med. 5, 101792 (2024), Abstract
Overcoming tumor heterogeneity by ex vivo arming of T cells using multiple bispecific antibodies.: Cheung, N. V., Park, J. A., et al.; J. Immunother. Cancer 10, (2022), Application(s): IHC, Abstract
Assessment of Antitumor and Antiproliferative Efficacy and Detection of Protein-Protein Interactions in Cancer Cells from 3D Tumor Spheroids.: Sonju, J. J., Dahal, A., et al.; Curr. Protoc. 2, e569 (2022), Reactant(s): Human, Abstract
Overcoming Tumor Heterogeneity by Ex Vivo Arming of T Cells Using Multiple Bispecific Antibodies: Cheung, N. V., Park, J. A., et al.; bioRxiv , (2021), Application(s): IHC
Theranostic pretargeted radioimmunotherapy of internalizing solid tumor antigens in human tumor xenografts in mice: Curative treatment of HER2-positive breast carcinoma.: Xu, H., Guo, H. F., et al.; Theranostics 8, 5106 (2018), Application(s): IHC / Reactant(s): Mouse, Abstract
Overcoming resistance to HER2-targeted therapy with a novel HER2/CD3 bispecific antibody.: Xu, H., Cheung, N. K., et al.; Oncoimmunology 6, e1267891 (2017), Application(s): IHC, Abstract
A comparative evaluation of the chelators H4octapa and CHX-A″-DTPA with the therapeutic radiometal (90)Y.: Lewis, J. S., Carlin, S. D., et al.; Nucl. Med. Biol. 43, 566 (2016), Application(s): IHC, Abstract
Multicolor microRNA FISH effectively differentiates tumor types.: Moore, P. S., Chang, Y., et al.; J. Clin. Invest. 123, 2694 (2013), Application(s): IHC / Reactant(s): Mouse, Abstract

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C-erbB-2 (human) clonal antibody (A24-V)

ALX-810-227

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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