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C. difficile toxin B

BML-G150

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High potency retained following inactivation
Minimal lot-to-lot variation
Lyophilized for ease of handling and long term stability

Extremely potent cytotoxin.

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Product Details

Alternative Name	Clostridium difficile toxin B
Appearance	Clear residue.
Biological Activity	2 pg/ml by verocytotoxicity assay (lowest point at which cell rounding is visible)
Formulation	Lyophilized. Contains 0.05M HEPES, 0.15M sodium chloride and 5% sucrose.
Purity	≥95% (SDS-PAGE)
Purity Detail	Purified protein.
Reconstitution	Reconstitute in 250µl sterile distilled water.
Source	From Clostridium difficile, strain VPI10463.
UniProt ID	P18177

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	After reconstitution, prepare aliquots and store at -80°C.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

PhosphoLipidome Alteration Induced by Clostridioides difficile Toxin B in Enteric Glial Cells: Buratta, S., Urbanelli, L., et al.; Cells 13, (2024), Abstract
Pro-Inflammatory Cytokines Enhanced In Vitro Cytotoxic Activity of Clostridioides difficile Toxin B in Enteric Glial Cells: The Achilles Heel of Clostridioides difficile Infection?: Fettucciari, K., Spaterna, A., et al.; Int. J. Mol. Sci. 25, (2024), Abstract
NLRP3 inflammasome activation and symptom burden in KRAS-mutated CMML patients is reverted by IL-1 blocking therapy: Hurtado-Navarro, L., Cuenca-Zamora, E. J., et al.; Cell Rep. Med. 4, 101329 (2023), Abstract
Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon: A.P. Franch, et al.; Elife 11, e73675 (2022), Abstract
Clostridioides difficile toxin B alone and with pro-inflammatory cytokines induces apoptosis in enteric glial cells by activating three different signalling pathways mediated by caspases, calpains and cathepsin B: K. Fettucciari, et al.; Cell. Mol. Life Sci. 79, 442 (2022), Abstract
Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation: Tapia-Abellán, A., Angosto-Bazarra, D., et al.; Sci. Adv. 7, eabf4468 (2021), Abstract
Extra-Intestinal Effects of C.difficile Toxin A and B: An In Vivo Study Using the Zebrafish Embryo Model: Tonon, F., Di Bella, S., et al.; Cells 9, (2020), Abstract
Clostridium difficile toxin B induces senescence in enteric glial cells: A potential new mechanism of Clostridium difficile pathogenesis: Fettucciari, K., Macchioni, L., et al.; Biochim. Biophys. Acta Mol. Cell Res. 1865, 1945 (2018), Abstract
Enteric glial cells are susceptible to Clostridium difficile toxin B: K. Fettucciari, et al.; Cell. Mol. Life Sci. 74, 1527 (2017), Abstract

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